| Identification | Back Directory | [Name]
2-Propenamide, N-[3-[[2-[(3-cyanophenyl)amino]thieno[3,2-d]pyrimidin-4-yl]oxy]phenyl]- | [CAS]
2459932-81-9 | [Synonyms]
EGFR-IN-49
2-Propenamide, N-[3-[[2-[(3-cyanophenyl)amino]thieno[3,2-d]pyrimidin-4-yl]oxy]phenyl]- | [Molecular Formula]
C22H15N5O2S | [MOL File]
2459932-81-9.mol | [Molecular Weight]
413.45 |
| Hazard Information | Back Directory | [Uses]
EGFR-IN-49 is a potent and selective EGFR inhibitor with IC50s of 65.0 nM and 13.6 nM for EGFRT790M and EGFRT790M/L858R, respectively. EGFR-IN-49 induces late apoptosis in a dose-dependent manner[1]. | [IC 50]
EGFRT790M: 65.0 nM (IC50); EGFRL858R/T790M: 13.6 nM (IC50) | [References]
[1] Xiao Z, et al. Design, synthesis and antitumor activity of novel thiophene-pyrimidine derivatives as EGFR inhibitors overcoming T790M and L858R/T790M mutations. Eur J Med Chem. 2020 Oct 1;203:112511. DOI:10.1016/j.ejmech.2020.112511 |
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