| Identification | Back Directory | [Name]
2-HYDROXY-4-NITRO-BENZALDEHYDE | [CAS]
2460-58-4 | [Synonyms]
NSC 82622
4-nitrosalicylaldehyde
Salicylaldehyde, 4-nitro-
2-HYDROXY-4-NITRO-BENZALDEHYDE
BENZALDEHYDE, 2-HYDROXY-4-NITRO- | [EINECS(EC#)]
219-549-4 | [Molecular Formula]
C7H5NO4 | [MDL Number]
MFCD00049373 | [MOL File]
2460-58-4.mol | [Molecular Weight]
167.119 |
| Chemical Properties | Back Directory | [Appearance]
Yellow Crystalline Solid | [Melting point ]
128-130°C | [Boiling point ]
309.2±32.0 °C(Predicted) | [density ]
1.500±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Chloroform, Dichloromethane, Methanol, | [form ]
Solid | [pka]
6.37±0.19(Predicted) | [color ]
Yellow Crystalline |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Crystalline Solid | [Uses]
2-Hydroxy-4-nitrobenzaldehyde (cas# 2460-58-4) is a compound useful in organic synthesis. | [Synthesis]
2-(Hydroxymethyl)-5-nitrophenol (13 g, 77 mmol) was mixed with manganese dioxide (26.7 g, 308 mmol) in ethyl acetate (250 mL). The reaction mixture was heated to 80 °C and the reaction was stirred at this temperature for 16 hours. After completion of the reaction, insoluble material was removed by filtration and the filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography with the eluent of petroleum ether/ethyl acetate (1:3, v/v) to give 2-hydroxy-4-nitrobenzaldehyde (10.5 g) in 81.7% yield. | [References]
[1] Journal of the Iranian Chemical Society, 2017, vol. 14, # 9, p. 1917 - 1933
[2] Synlett, 2003, # 12, p. 1868 - 1870
[3] Journal of the American Chemical Society,
[4] Journal of the American Chemical Society, 2009, vol. 131, p. 1187 - 1194
[5] Patent: CN106349233, 2017, A. Location in patent: Paragraph 0119; 0123; 0124; 0125 |
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