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247037-81-6

247037-81-6 Structure

247037-81-6 Structure
IdentificationBack Directory
[Name]

methyl (R)-4-(2-chloro-4-fluorophenyl)-6-methyl-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
[CAS]

247037-81-6
[Synonyms]

BAY395493
BAY-395493
BAY 395493
BAY39-5493
BAY 39-5493
BAY-39-5493
BAY395493,BAY39 5493
Ethyl (R)-4-(2-Chloro-4-fluorophenyl)-6-methyl-2-(2-thiazolyl)-1,4-dihydropyrimidine-5-carboxylate
(R)-ethyl 4-(2-chloro-4-fluorophenyl)-6-methyl-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
methyl (R)-4-(2-chloro-4-fluorophenyl)-6-methyl-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
5-Pyrimidinecarboxylic acid, 4-(2-chloro-4-fluorophenyl)-1,4-dihydro-6-methyl-2-(2-thiazolyl)-, ethyl ester, (4R)-
[Molecular Formula]

C17H15ClFN3O2S
[MOL File]

247037-81-6.mol
[Molecular Weight]

379.84
Hazard InformationBack Directory
[Uses]

BAY39-5493 is a non-nucleoside inhibitor that inhibits HBV replication. BAY39-5493 inhibits viral DNA replication by preventing the formation of viral core particles (nucleocapsids). The IC50 value of BAY39-5493 against HBV in stably transfected HepG2.2.15 cells is 0.03 μM[1].
[References]

[1] Deres K, et al. Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids[J]. Science, 2003, 299(5608): 893-896. DOI:10.1126/science.1077215
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