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YS-363 is a potent, selective, and orally active EGFR inhibitor, with IC50s of 0.96 nM and 0.67 nM for wild-type and L858R mutant forms of EGFR, respectively. YS-363 can induce G0/G1 cell cycle arrest and apoptosis[1]. | [IC 50]
EGFR: 0.96 nM (IC50) | [References]
[1] He P, et, al. Discovery of YS-363 as a highly potent, selective, and orally e?cacious EGFR inhibitor. Biomed Pharmacother. 2023 Nov:167:115491. DOI:10.1016/j.biopha.2023.115491 |
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