2471972-15-1

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2471972-15-1 Structure

Identification	Back Directory
[Name] Cyclopropanecarboxamide, N-[6-[3-[[[(2-methylpropyl)sulfonyl]amino]methyl]phenyl]-1H-indazol-3-yl]-
[CAS] 2471972-15-1
[Synonyms] Cyclopropanecarboxamide, N-[6-[3-[[[(2-methylpropyl)sulfonyl]amino]methyl]phenyl]-1H-indazol-3-yl]-
[Molecular Formula] C22H26N4O3S
[MOL File] 2471972-15-1.mol
[Molecular Weight] 426.53

Chemical Properties	Back Directory
[density ] 1.352±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 10.40±0.40(predicted)

Hazard Information	Back Directory
[Uses] CDK-IN-14 (Compound 9) is a potent and selective CDKL2 (Cyclin-dependent kinase-like 2) inhibitor with an IC50 value of 460 nM. CDKL2 is involved in various biological processes such as tumorigenesis, development, and viral infections. CDK-IN-14 serves as a powerful tool for studying the biological functions of CDKL2 and holds promise for research in fields related to cancer, infections, and other diseases[1].
[References] [1] Bashore F M, et al. Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2[J]. bioRxiv, 2024. DOI:10.1101/2024.05.12.593776

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