| Identification | Back Directory | [Name]
Spongosine | [CAS]
24723-77-1 | [Synonyms]
GL101375
BVT-115959
Spongosine
2-Methoxyadenosine
Adenosine, 2-methoxy-
Regadenoson Impurity 59
Spongosine, 10 mM in DMSO
Regadenoson Impurity 8 (Spongosine)
2-Methoxy-9-pentofuranosyl-9H-purin-6-amine
2-Methoxyadenosine, Spongosine, Regadenosone impurity 8 | [Molecular Formula]
C11H15N5O5 | [MDL Number]
MFCD28502081 | [MOL File]
24723-77-1.mol | [Molecular Weight]
297.27 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at 0-8 °C | [solubility ]
DMSO: Slightly soluble: 0.1-1 mg/ml | [Boiling point ]
705.0±70.0 °C(Predicted) | [density ]
1.98±0.1 g/cm3(Predicted) | [form ]
Solid | [Melting point ]
193 °C | [pka]
13.07±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Spongosine (2-Methoxyadenosine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. | [References]
[1] Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500. DOI:10.1016/j.drudis.2021.02.020
[2] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
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