| Identification | Back Directory | [Name]
12-[[2-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]oxyacetyl]amino]dodecanoic acid | [CAS]
2473270-96-9 | [Synonyms]
Thalidomide-O-amido-C11-COOH
12-[[2-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]oxyacetyl]amino]dodecanoic acid | [Molecular Formula]
C27H35N3O8 | [MOL File]
2473270-96-9.mol | [Molecular Weight]
529.58 |
| Chemical Properties | Back Directory | [Boiling point ]
827.1±65.0 °C(Predicted) | [density ]
1.288±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
4.78±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Thalidomide-O-amido-C11-COOH (compound IMiD acid 1) is an E3 ligase ligand and linker CRBN (Cereblon) conjugate. Thalidomide-O-amido-C11-COOH can be used to synthesize PROTAC that target the degradation of DOT1L[1]. | [References]
[1] Jun Qi, et al. Small molecules for dot1l degradation and uses thereof. Patent WO2023069348A1. |
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