ChemicalBook--->CAS DataBase List--->24751-69-7

24751-69-7

24751-69-7 Structure

24751-69-7 Structure
IdentificationBack Directory
[Name]

nucleocidin
[CAS]

24751-69-7
[Synonyms]

T-3018
NSC 521007
nucleocidin
Antibiotic T-3018
LTBCQBSAWAZBDF-XPQPFPQWSA-N
4'-Fluoro-5'-O-sulfamoyladenosine
5'-O-Sulfamoyl-4'-fluoroadenosine
Adenosine, 4'-C-fluoro-, 5'-sulfamate
Sulfamic acid 4'-fluoro-5'-adenosyl ester
[Molecular Formula]

C10H13FN6O6S
[MDL Number]

MFCD01939321
[MOL File]

24751-69-7.mol
[Molecular Weight]

364.31
Chemical PropertiesBack Directory
[Melting point ]

>190° (dec)
[Boiling point ]

747.6±70.0 °C(Predicted)
[density ]

2.23±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[pka]

9.15±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

Nucleocidin is used in studies relating to novel parasite inhibitors.
[Definition]

ChEBI: Nucleocidin is a nucleoside antibiotic that is 5'-O-sulfamoyladenosine in which the hydrogen atom at position 4' is replaced by a fluorine atom. It is a natural product synthesized by several Streptomyces species. It exhibits broad spectrum antibacterial activity, and also has a strong effect against Trypanosoma brucei, the protozoan parasite responsible for the African sleeping sickness. It has a role as a bacterial metabolite, an antibacterial agent, a trypanocidal drug, a protein synthesis inhibitor and a nucleoside antibiotic. It is a member of adenosines, an organofluorine compound, a sulfamate ester, a member of 6-aminopurines and a diol. It is functionally related to an adenosine.
[storage]

Store at -20°C
Safety DataBack Directory
[Toxicity]

LD50 i.p. in mice: ~0.2 mg/kg (Thomas)
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