| Identification | Back Directory | [Name]
Thiourea, N-(5-chloro-2-methoxyphenyl)-N'-[1-[6-(trifluoromethyl)-2-pyridinyl]-4-piperidinyl]- | [CAS]
2477651-11-7 | [Synonyms]
USP8-IN-2
Thiourea, N-(5-chloro-2-methoxyphenyl)-N'-[1-[6-(trifluoromethyl)-2-pyridinyl]-4-piperidinyl]- | [Molecular Formula]
C19H20ClF3N4OS | [MOL File]
2477651-11-7.mol | [Molecular Weight]
444.9 |
| Chemical Properties | Back Directory | [Boiling point ]
532.3±60.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
12.22±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
USP8-IN-2 (Compd U52) is a deubiquitinase USP8 inhibitor with an IC50 value of 6.0 μM. USP8-IN-2 also inhibits the proliferation of H1957 cells with an GI50 value of 24.93 μM, respectively[1]. | [IC 50]
USP8: 6.0 μM (IC50) | [References]
[1] Li zhiyun, et al. Preparing method and application of USP8 inhibitor: China, CN111138358 A. 2020-05-12. |
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