| Identification | Back Directory | [Name]
Copper, tribromobis[μ-[methyl N-[di(2-pyridinyl-κN)methylene]carbonodithiohydrazonato-κN,κS']]tri- | [CAS]
2480150-28-3 | [Synonyms]
Copper, tribromobis[μ-[methyl N-[di(2-pyridinyl-κN)methylene]carbonodithiohydrazonato-κN,κS']]tri- | [Molecular Formula]
C26H27Br3Cu3N8S4 | [MOL File]
2480150-28-3.mol | [Molecular Weight]
1010.15 |
| Hazard Information | Back Directory | [Description]
Complex 3 is a fluorescent dithiocarbazate-copper complex with anticancer activity.1 It localizes to mitochondria and displays excitation/emission maxima of 455-495/535 nm, respectively. Complex 3 inhibits the growth of BxPC-3, AsPC-1, PANC-1, and WI38 pancreatic cancer cells (IC50s = 0.74, 0.41, 0.62, and 2.06 μM, respectively). It induces lipid peroxidation and mitochondrial rupture and shrinkage in AsPC-1 cells, effects that can be reduced by the ferroptosis inhibitor liproxstatin-1 . Complex 3 also induces mitochondrial apoptosis and cytokine-cytokine receptor interaction dysfunction in the same cells. In vivo, complex 3 (1.5 and 3 mg/kg) reduces tumor volume and intratumor apoptosis in an AsPC-1 mouse xenograft model. | [Uses]
Complex 3 is a fluorescent dithiocarbazate-copper complex with anticancer activity, which localizes to mitochondria. Complex 3 displays excitation/emission maxima of 455-495/535 nm, respectively. Complex 3 inhibits the growth of BxPC-3, AsPC-1, PANC-1, and WI38 pancreatic cancer cells with IC50 values of 0.74, 0.41, 0.62, and 2.06 μM, respectively. Complex 3 induces lipid peroxidation and mitochondrial rupture and shrinkage in AsPC-1 cells. Complex 3 also induces mitochondrial apoptosis and cytokine-cytokine receptor interaction dysfunction in AsPC-1 cells. Complex 3 reduces tumor volume in an AsPC-1 mouse xenograft model[1]. | [References]
1. Guo, Y., Chen, M., Li, S., et al. Dithiocarbazate-copper complexes for bioimaging and treatment of pancreatic cancer J. Med. Chem. 64(9),5485-5499(2021). |
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