| Identification | Back Directory | [Name]
11H-Indeno[1,2-b]quinoxalin-11-one, 2-[5-[2-(4-chlorophenyl)diazenyl]-4-methyl-2-thiazolyl]hydrazone | [CAS]
2482310-18-7 | [Synonyms]
Apoptotic agent-2
11H-Indeno[1,2-b]quinoxalin-11-one, 2-[5-[2-(4-chlorophenyl)diazenyl]-4-methyl-2-thiazolyl]hydrazone | [Molecular Formula]
C25H16ClN7S | [MOL File]
2482310-18-7.mol | [Molecular Weight]
481.96 |
| Hazard Information | Back Directory | [Uses]
Apoptotic agent-2 (compound 14b) induces apoptosis by down-regulation of Bcl-2 and up-regulation of Bax and caspase-3. Apoptotic agent-2 exhibits anti-proliferative activities and can be used for cancer research[1]. | [IC 50]
Bax; Caspase 3; Bcl-2 | [References]
[1] Fayed EA, et al. In vitro cytotoxic activity of thiazole-indenoquinoxaline hybrids as apoptotic agents, design, synthesis, physicochemical and pharmacokinetic studies. Bioorg Chem. 2020 Jul;100:103951. DOI:10.1016/j.bioorg.2020.103951 |
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