| Identification | Back Directory | [Name]
11H-Indeno[1,2-b]quinoxalin-11-one, 2-[4-(4-methoxyphenyl)-3-phenyl-2(3H)-thiazolylidene]hydrazone | [CAS]
2482310-23-4 | [Synonyms]
Apoptotic agent-3
11H-Indeno[1,2-b]quinoxalin-11-one, 2-[4-(4-methoxyphenyl)-3-phenyl-2(3H)-thiazolylidene]hydrazone | [Molecular Formula]
C31H21N5OS | [MOL File]
2482310-23-4.mol | [Molecular Weight]
511.6 |
| Hazard Information | Back Directory | [Uses]
Apoptotic agent-3 (compound 15f) promotes apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway and activation of the Caspase 3 pathway. Apoptotic agent-3 exhibits anti-proliferative activities and can be used for cancer research[1]. | [IC 50]
Caspase 3; Bcl-2; Bax | [References]
[1] Fayed EA, et al. In vitro cytotoxic activity of thiazole-indenoquinoxaline hybrids as apoptotic agents, design, synthesis, physicochemical and pharmacokinetic studies. Bioorg Chem. 2020 Jul;100:103951. DOI:10.1016/j.bioorg.2020.103951 |
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