| Identification | Back Directory | [Name]
2H-1,4-Benzoxazine-8-carboxamide, 3,4-dihydro-2-[(4-hydroxyphenyl)methylene]-3-oxo-, (2Z)- | [CAS]
2482484-87-5 | [Synonyms]
PARP1-IN-11
2H-1,4-Benzoxazine-8-carboxamide, 3,4-dihydro-2-[(4-hydroxyphenyl)methylene]-3-oxo-, (2Z)- | [Molecular Formula]
C16H12N2O4 | [MOL File]
2482484-87-5.mol | [Molecular Weight]
296.28 |
| Chemical Properties | Back Directory | [Boiling point ]
576.4±50.0 °C(Predicted) | [density ]
1.447±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
8.85±0.30(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
PARP1-IN-11 (compound 49) is a potent PARP1 inhibitor with IC50 value of 0.082 μM. PARP1-IN-11 shows complete inhibition of PARP2 and substantially inhibits PARP3, TNKS1 and TNKS2[1]. | [IC 50]
PARP1: 0.082 μM (IC50); PARP2; TNKS1; TNKS2 | [References]
[1] Shao X, et al. Synthesis of 2,3-dihydrobenzo[b][1,4]dioxine-5-carboxamide and 3-oxo-3,4-dihydrobenzo[b][1,4]oxazine-8-carboxamide derivatives as PARP1 inhibitors. Bioorg Chem. 2020 Sep;102:104075. DOI:10.1016/j.bioorg.2020.104075 |
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