| Identification | Back Directory | [Name]
2-(AMINOMETHYL)PHENYL BORONIC ACID | [CAS]
248274-03-5 | [Synonyms]
2-(AMINOMETHYL)PHENYL BORONIC ACID
2-(Aminomethyl)phenyl boronic acid 95%
Boronic acid, B-[2-(aminomethyl)phenyl]- | [Molecular Formula]
C7H10BNO2 | [MDL Number]
MFCD06212997 | [MOL File]
248274-03-5.mol | [Molecular Weight]
150.97 |
| Chemical Properties | Back Directory | [Boiling point ]
354.0±44.0 °C(Predicted) | [density ]
1.18±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
8.23±0.53(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of (2-(aminomethyl)phenyl)boronic acid from 2-cyanophenylboronic acid was as follows: to a methanol solution (20 mL) containing 2-cyanophenylboronic acid (300 mg, 2.0 mmol) was added nickel ryenne (100 mg, 10% w/w). The reaction mixture was stirred for 4 h at room temperature under hydrogen pressure of 50 psi. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated under vacuum to afford (2-(aminomethyl)phenyl)boronic acid 150 mg (48.7% yield) as a white solid. Mass spectrum (electrospray positive ion mode): m/z = 152.20, 153.40, 154.35, 155.65 [M + H]+. Analyzed by liquid chromatography-mass spectrometry: retention time tR = 0.76 min. | [References]
[1] Patent: WO2015/81280, 2015, A1. Location in patent: Paragraph 00497; 00498 |
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Cool Pharm, Ltd
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