| Identification | Back Directory | [Name]
Benz[5,6]isoindolo[1,2-b]quinazolin-14(12H)-one, 2-fluoro-3-(1-piperazinyl)- | [CAS]
2485135-31-5 | [Synonyms]
Topoisomerase I inhibitor 4
Benz[5,6]isoindolo[1,2-b]quinazolin-14(12H)-one, 2-fluoro-3-(1-piperazinyl)- | [Molecular Formula]
C23H19FN4O | [MOL File]
2485135-31-5.mol | [Molecular Weight]
386.42 |
| Hazard Information | Back Directory | [Uses]
Topoisomerase I inhibitor 4 (compound 7a) is a topoisomerase I inhibitor. Topoisomerase I inhibitor 4 inhibits HepG2, A549, MCF-7 and HeLa cancer cells proliferation with IC50s of 1.20, 2.09, 1.56 and 1.92 μM, respectively. Topoisomerase I inhibitor 4 can be used for the research of cancer[1]. | [References]
[1] Xiang, Y, et al. Design, synthesis, and anticancer activities of 8,9-substituted Luotonin A analogs as novel topoisomerase I inhibitors. Med Chem Res 30, 1512–1522 (2021). |
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