| Identification | Back Directory | [Name]
1H-Pyrazole-1-carboxamide, 5-[5-bromo-1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-1H-indol-3-yl]-4,5-dihydro-3-[4-(trifluoromethyl)phenyl]-, (5S)- | [CAS]
2485758-50-5 | [Synonyms]
JAK2/STAT3-IN-1
1H-Pyrazole-1-carboxamide, 5-[5-bromo-1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-1H-indol-3-yl]-4,5-dihydro-3-[4-(trifluoromethyl)phenyl]-, (5S)- | [Molecular Formula]
C34H35BrF3N5O2 | [MOL File]
2485758-50-5.mol | [Molecular Weight]
682.57 |
| Hazard Information | Back Directory | [Uses]
JAK2/STAT3-IN-1 (compound (S)-10a) is a potent GP130 inhibitor with an IC50 of 3.04 μM. JAK2/STAT3-IN-1 shows anti-tumor activity[1]. | [References]
[1] Song D, et al. Discovery of bazedoxifene analogues targeting glycoprotein 130. Eur J Med Chem. 2020 Aug 1;199:112375. DOI:10.1016/j.ejmech.2020.112375 |
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