| Identification | Back Directory | [Name]
1H-Indole-7-carboxylic acid, 1-[(2S)-2-[3-[(3S)-3-amino-2,3-dihydro-5-benzofuranyl]-5-(1-methylethyl)phenyl]-2-hydroxyethyl]- | [CAS]
2488952-56-1 | [Synonyms]
FXIa-IN-7
1H-Indole-7-carboxylic acid, 1-[(2S)-2-[3-[(3S)-3-amino-2,3-dihydro-5-benzofuranyl]-5-(1-methylethyl)phenyl]-2-hydroxyethyl]- | [Molecular Formula]
C28H28N2O4 | [MOL File]
2488952-56-1.mol | [Molecular Weight]
456.53 |
| Hazard Information | Back Directory | [Uses]
FXIa-IN-7 is a selective and orally bioavailable factor XIa inhibitor with an IC50 value of 0.4 nM. | [References]
[1] Lorthiois E, et al. Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach. J Med Chem. 2020 Aug 13;63(15):8088-8113. DOI:10.1021/acs.jmedchem.0c00279 |
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