| Identification | Back Directory | [Name]
Guanidine, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-N'-[1,6-dihydro-4-[[(4-methylphenyl)thio]methyl]-6-oxo-2-pyrimidinyl]-, [C(E)]- | [CAS]
2489231-47-0 | [Synonyms]
CHET3
Guanidine, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-N'-[1,6-dihydro-4-[[(4-methylphenyl)thio]methyl]-6-oxo-2-pyrimidinyl]-, [C(E)]- | [Molecular Formula]
C21H21N5O3S | [MOL File]
2489231-47-0.mol | [Molecular Weight]
423.49 |
| Hazard Information | Back Directory | [Uses]
CHET3 is a sex-selective activator with potent analgesic activity. CHET3 was discovered to be a highly selective omnidirectional modulator of TASK-3-containing K2P channels, including TASK-3 homologues and TASK-3/TASK-1 heterologues. CHET3 exhibited significant analgesic effects in multiple acute and chronic pain models in mice, which could be abolished by pharmacological means or genetic knockout of TASK-3. CHET3 is able to functionally modulate the membrane excitability of specific small sensory neurons, which supports its analgesic effects on thermal hypersensitivity and mechanical hyperalgesia in chronic pain[1]. | [References]
[1] Selective activation of TWIK-related acid-sensitive K+ 3 subunit-containing channels is analgesic in rodent models |
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