| Identification | Back Directory | [Name]
Urea, N-[1-[4-[(6-chloro-1,2,3,4-tetrahydro-9-acridinyl)amino]-1-oxobutyl]-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]- | [CAS]
2490589-09-6 | [Synonyms]
sEH/AChE-IN-2
Urea, N-[1-[4-[(6-chloro-1,2,3,4-tetrahydro-9-acridinyl)amino]-1-oxobutyl]-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]- | [Molecular Formula]
C30H33ClF3N5O3 | [MOL File]
2490589-09-6.mol | [Molecular Weight]
604.06 |
| Hazard Information | Back Directory | [Uses]
sEH/AChE-IN-2 (Compound 12b) is a dual inhibitor of the enzymes soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE). sEH/AChE-IN-2 provides cumulative effects against neuroinflammation and memory impairment. sEH/AChE-IN-2 has the potential for the research of Alzheimer's disease (AD)[1]. | [References]
[1] Codony S, et al. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. J Med Chem. 2022;65(6):4909-4925. DOI:10.1021/acs.jmedchem.1c02150 |
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