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2490599-18-1

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2490599-18-1 Structure

2490599-18-1 Structure
IdentificationBack Directory
[Name]

GMB-475
[CAS]

2490599-18-1
[Synonyms]

GMB-475
(2S,4R)-1-((S)-3,3-Dimethyl-2-(2-(2-(4-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)phenoxy)ethoxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
[Molecular Formula]

C43H46F3N7O7S
[MOL File]

2490599-18-1.mol
[Molecular Weight]

861.94
Chemical PropertiesBack Directory
[solubility ]

DMSO:145.4(Max Conc. mg/mL);168.69(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);58.01(Max Conc. mM)
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard InformationBack Directory
[Description]

GMB-475 acts as a degrader of BCR-ABL 1 tyrosine kinase and as a recruiter of the E3 ligase Von Hippel Lindau (VHL) resulting in ubiquitination and subsequent degradation of oncogenic fusion proteins.
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

GMB-475(2490599-18-1)1HNMR
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