| Identification | Back Directory | [Name]
4H-Pyran-4-one, 3-[2-[4-(4-fluorobenzoyl)-1-piperazinyl]ethoxy]-2-methyl- | [CAS]
2490699-40-4 | [Synonyms]
LDHA/PDKs-IN-1
4H-Pyran-4-one, 3-[2-[4-(4-fluorobenzoyl)-1-piperazinyl]ethoxy]-2-methyl- | [Molecular Formula]
C19H21FN2O4 | [MOL File]
2490699-40-4.mol | [Molecular Weight]
360.38 |
| Hazard Information | Back Directory | [Uses]
LDHA/PDKs-IN-1 (compound 20e) is a potent and dual inhibitor of PDKs and LDHA with IC50s of 0.8 and 0.15 μM, respectively. LDHA/PDKs-IN-1 reduces A549 cell proliferation with an EC50 of 13.2 μM and decreases the lactate formation, and increases oxygen consumption. LDHA/PDKs-IN-1 has the potential for the research of cancer diseases[1]. | [References]
[1] Xiang S, et al. Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation. Eur J Med Chem. 2020;203:112579. DOI:10.1016/j.ejmech.2020.112579 |
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