| Identification | Back Directory | [Name]
Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide | [CAS]
2492376-85-7 | [Synonyms]
PI3K/mTOR Inhibitor-8
Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide | [Molecular Formula]
C23H22N8O4S | [MOL File]
2492376-85-7.mol | [Molecular Weight]
506.54 |
| Hazard Information | Back Directory | [Uses]
PI3K/mTOR Inhibitor-8 (Compound 18b) is a PI3K and mTOR dual inhibitor with IC50 values of 0.46 nM and 12 nM against PI3Kα and mTOR, respectively. PI3K/mTOR Inhibitor-8 induces HCT-116 cells apoptosis and arrests cell cycle at the G1/S phase[1]. | [IC 50]
PI3Kα: 0.46 nM (IC50); mTOR: 12 nM (IC50) | [References]
[1] Han Y, et al. Design, synthesis and biological evaluation of thieno[3,2-d]pyrimidine derivatives containing aroyl hydrazone or aryl hydrazide moieties for PI3K and mTOR dual inhibition. Bioorg Chem. 2020 Nov;104:104197. DOI:10.1016/j.bioorg.2020.104197 |
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