| Identification | Back Directory | [Name]
2-Furancarbothioic acid, S-(4,5-dihydro-4-oxo[1,2,4]triazolo[4,3-a]quinoxalin-1-yl) ester | [CAS]
2493298-68-1 | [Synonyms]
Topoisomerase II inhibitor 8
2-Furancarbothioic acid, S-(4,5-dihydro-4-oxo[1,2,4]triazolo[4,3-a]quinoxalin-1-yl) ester | [Molecular Formula]
C14H8N4O3S | [MOL File]
2493298-68-1.mol | [Molecular Weight]
312.3 |
| Hazard Information | Back Directory | [Uses]
Topoisomerase II inhibitor 8 (compound 22) is a potent topoisomerase II inhibitor, with an IC50 of 0.52 μM. Topoisomerase II inhibitor 8 exhibits good anti-proliferative activities and can arrest the cell cycle at G2/M phase[1]. | [IC 50]
Topoisomerase II: 0.52 μM (IC50) | [References]
[1] Abbass EM, et, al. Design, efficient synthesis, docking studies, and anticancer evaluation of new quinoxalines as potential intercalative Topo II inhibitors and apoptosis inducers. Bioorg Chem. 2020 Nov;104:104255. DOI:10.1016/j.bioorg.2020.104255 |
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