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2495742-21-5

2495742-21-5 Structure

2495742-21-5 Structure
IdentificationBack Directory
[Name]

10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 4-amino-9-ethyl-1,2,3,9,12,15-hexahydro-9-hydroxy-, (9S)-
[CAS]

2495742-21-5
[Synonyms]

(4-NH2)-Exatecan
10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 4-amino-9-ethyl-1,2,3,9,12,15-hexahydro-9-hydroxy-, (9S)-
[Molecular Formula]

C23H21N3O4
[MOL File]

2495742-21-5.mol
[Molecular Weight]

403.43
Chemical PropertiesBack Directory
[Boiling point ]

856.1±65.0 °C(Predicted)
[density ]

1.53±0.1 g/cm3(Predicted)
[storage temp. ]

4°C, away from moisture
[form ]

Solid
[pka]

11.23±0.20(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

(4-NH2)-Exatecan, a topoisomerase inhibitor, is a derivative of Exatecan. (4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs) (US20200306243A1, compound A)[1].
[Biological Activity]

(4-NH2)-Exatecan, a topoisomerase inhibitor derivative extracted from patent US20200306243A1, compound A. (4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs)[1].
[IC 50]

Camptothecins
[References]

[1]. Howard PW, et, al. Compounds and conjugates thereof. US20200306243A1.
Spectrum DetailBack Directory
[Spectrum Detail]

10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 4-amino-9-ethyl-1,2,3,9,12,15-hexahydro-9-hydroxy-, (9S)-(2495742-21-5)1HNMR
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