| Identification | Back Directory | [Name]
4-Thiazolidinone, 3-(3-methylphenyl)-2-[3-(2-oxo-2H-1-benzopyran-3-yl)-1-phenyl-1H-pyrazol-4-yl]- | [CAS]
2497504-72-8 | [Synonyms]
hCAIX-IN-10
4-Thiazolidinone, 3-(3-methylphenyl)-2-[3-(2-oxo-2H-1-benzopyran-3-yl)-1-phenyl-1H-pyrazol-4-yl]- | [Molecular Formula]
C28H21N3O3S | [MOL File]
2497504-72-8.mol | [Molecular Weight]
479.55 |
| Hazard Information | Back Directory | [Uses]
hCAIX-IN-10 (Compound 6i) is a selective carbonic anhydrase IX and XII inhibitor with Ki s of 61.5 and 586.8 nM for hCA IX and hCA XII, respectively. ?hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells[1]. | [IC 50]
CA Ⅸ | [References]
[1] Pavitra S Thacker,et al. Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem.?2020 Nov;104:104272. DOI:10.1016/j.bioorg.2020.104272 |
|
|