| Identification | Back Directory | [Name]
3H-1,2,4-Triazole-3-thione, 2,4-dihydro-4-[[(2-hydroxy-4-methoxyphenyl)methylene]amino]-5-[(4-methylphenyl)methyl]- | [CAS]
2497530-12-6 | [Synonyms]
COX-2-IN-19
3H-1,2,4-Triazole-3-thione, 2,4-dihydro-4-[[(2-hydroxy-4-methoxyphenyl)methylene]amino]-5-[(4-methylphenyl)methyl]- | [Molecular Formula]
C18H18N4O2S | [MOL File]
2497530-12-6.mol | [Molecular Weight]
354.43 |
| Hazard Information | Back Directory | [Uses]
COX-2-IN-19 (Compound 24) is a potent COX-2 inhibitor with an IC50 of 1.76 μM. COX-2-IN-19 shows in vivo anti-inflammatory activity[1]. | [IC 50]
COX-2: 1.76 μM (IC50); COX-1: 117.8 μM (IC50) | [References]
[1] Munir A, et al. Synthesis, in-vitro, in-vivo anti-inflammatory activities and molecular docking studies of acyl and salicylic acid hydrazide derivatives. Bioorg Chem. 2020 Nov;104:104168. DOI:10.1016/j.bioorg.2020.104168 |
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