| Identification | Back Directory | [Name]
(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide | [CAS]
2505001-62-5 | [Synonyms]
(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide
2-Propenamide, 3-(3,4-dichlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)-
(E)3(3,4dichlorophenyl)N(2(4(methylsulfonyl)piperazin1yl)2oxoethyl)acrylamide,(E) 3 (3,4 dichlorophenyl) N (2 (4 (methylsulfonyl)piperazin 1 yl) 2 oxoethyl)acrylamide | [Molecular Formula]
C16H19Cl2N3O4S | [MDL Number]
MFCD32693929 | [MOL File]
2505001-62-5.mol | [Molecular Weight]
420.31 |
| Hazard Information | Back Directory | [Uses]
SR18662 is a potent inhibitor of Krüppel-like factor five (KLF5) with an IC50?of 4.4 nM and an analogue of ML264 (HY-19994) with improved inhibitory potency against colorectal cancer cells. SR18662 can be used for the study of colorectal cancer[1]. | [in vivo]
SR18662 (intraperitoneal injection; 5-10 mg/kg; daily or twice daily; 5 days injection, days break, and 5 days) significantly reduces the growth of tumors in a mouse xenograft model[1]. | Animal Model: | Nude mice with DLD-1 cells[1] | | Dosage: | 5 mg/kg; 10 mg/kg; 25 mg/kg | | Administration: | Intraperitoneal injection; 5mg/kg daily, 5mg/kg twice a day,10 mg/kg daily, 10 mg/kg twice per day, 25mg/kg daily, and 25 mg/kg twice per day; 5 days of injections, 2 days break, and 5 days of injections | | Result: | Caused a significant dose-dependent inhibition of xenograft growth in mice. |
| [References]
[1] Julie Kim,et al.The Novel Small-Molecule SR18662 Efficiently Inhibits the Growth of Colorectal Cancer?In Vitroand?In Vivo.Mol Cancer Ther.2019 Nov;18(11):1973-1984. DOI:10.1158/1535-7163.MCT-18-1366 |
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| Company Name: |
ChemCell Biomedicine Co.,Ltd.
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| Tel: |
020-13556033878 2965585218 13556033878 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15061/0_EN.htm |
| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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