| Identification | Back Directory | [Name]
4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]- | [CAS]
2505339-54-6 | [Synonyms]
BR102910
(S)-N-[2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl]-2-(3,4-dichlorobenzyl)thiazole-4-carboxamide
4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]- | [Molecular Formula]
C18H14Cl2F2N4O2S | [MDL Number]
MFCD34565708 | [MOL File]
2505339-54-6.mol | [Molecular Weight]
459.3 |
| Chemical Properties | Back Directory | [Boiling point ]
734.5±60.0 °C(Predicted) | [density ]
1.55±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
12.68±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
BR102910 is a selective fibroblast activation protein (FAP) inhibitor with the IC50 of 2 nM. BR102910 also inhibits prolyl oligopeptidase (PREP) with the IC50 of 49.00 μM. BR102910 can be used for the researchof type 2 | [Biological Activity]
BR102910 is a selective fibroblast activation protein (FAP) inhibitor with the IC50 of 2 nM. BR102910 also inhibits prolyl oligopeptidase (PREP) with the IC50 of 49.00 μM. BR102910 can be used for the researchof type 2
BR102910 (C57BL/6J mice, 0-30 mg/kg, Orally, once) shows significant FAP inhibition in a dose dependent manner[1]. | [in vivo]
BR102910 (C57BL/6J mice, 0-30 mg/kg, Orally, once) shows significant FAP inhibition in a dose dependent manner[1]. | Animal Model: | C57BL/6J mice (n = 5 per group)[1] | | Dosage: | 0, 10 and 30 mg/kg | | Administration: | Orally, once | | Result: | Showed significant FAP inhibition in a dose dependent manner. |
| [References]
[1]. Hui Jin Jung, et al. Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor. Bioorg Med Chem Lett. 2021 Apr 1;37:127846. |
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