| Hazard Information | Back Directory | [Uses]
SAP2-IN-1 is a secreted aspartic protease 2 (SAP2) inhibitor and has potent SAP2 inhibitory activity with an IC50 value of 0.92 μM. SAP2-IN-1 also is a virulence factor inhibitor and is inactive in vitro. SAP2-IN-1 can be used for the research of infection[1]. | [in vivo]
SAP2-IN-1 (compound 24a) (i.p.; 10 mg/kg; once daily; for four days) shows potent in vivo efficacy in a murine model of invasive candidiasis[1]. | Animal Model: | a murine model of invasive candidiasis[1] | | Dosage: | 10 mg/kg | | Administration: | intraperitoneally administration, once daily, for four days | | Result: | Significantly reduced the fungal burden in the kidney. |
| [References]
[1] Chenglan Li, et al. Targeting fungal virulence factor by small molecules: Structure-based discovery of novel secreted aspartic protease 2 (SAP2) inhibitors. Eur J Med Chem. 2020 Sep 1;201:112515. DOI:10.1016/j.ejmech.2020.112515 |
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