| Identification | Back Directory | [Name]
Glycine, N-[4-[3-(acetylamino)-1-propyn-1-yl]benzoyl]- | [CAS]
2515609-54-6 | [Synonyms]
Glycine, N-[4-[3-(acetylamino)-1-propyn-1-yl]benzoyl]- | [Molecular Formula]
C14H14N2O4 | [MOL File]
2515609-54-6.mol | [Molecular Weight]
274.27 |
| Chemical Properties | Back Directory | [Boiling point ]
627.9±50.0 °C(predicted) | [density ]
1.31±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
3.51±0.10(predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
AACA is an inhibitor for sclerostin, that binds sclerostin on loop3 region with Kd of 15.4 nM. AACA exhibits anti-osteoporosis activity through Wnt signaling pathway[1]. | [References]
[1] Yu S, et al., Discovery of the small molecular inhibitors against sclerostin loop3 as potential anti-osteoporosis agents by structural based virtual screening and molecular design. Eur J Med Chem. 2024 Apr 16;271:116414. DOI:10.1016/j.ejmech.2024.116414 |
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