| Identification | Back Directory | [Name]
N-(2-Methoxyphenyl)-N′-2-naphthalenyl-urea | [CAS]
251917-79-0 | [Synonyms]
BLT-4
INF 271
MIT 9952-29
BLT-4 >=98% (HPLC)
N-(2-Methoxyphenyl)-N′-2-naphthalenyl-urea
Urea, N-(2-methoxyphenyl)-N'-2-naphthalenyl- | [Molecular Formula]
C18H16N2O2 | [MDL Number]
MFCD00406317 | [MOL File]
251917-79-0.mol | [Molecular Weight]
292.33 |
| Chemical Properties | Back Directory | [Boiling point ]
393.3±25.0 °C(Predicted) | [density ]
1.282±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: soluble15mg/mL (clear solution) | [form ]
powder | [pka]
13.78±0.70(Predicted) | [color ]
white to beige | [InChI]
1S/C18H16N2O2/c1-22-17-9-5-4-8-16(17)20-18(21)19-15-11-10-13-6-2-3-7-14(13)12-15/h2-12H,1H3,(H2,19,20,21) | [InChIKey]
ISADADAHPHHLEM-UHFFFAOYSA-N | [SMILES]
COc1ccccc1NC(=O)Nc2ccc3ccccc3c2 |
| Safety Data | Back Directory | [Hazard Codes ]
N | [Risk Statements ]
50/53 | [Safety Statements ]
60-61 | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Aquatic Acute 1
Aquatic Chronic 1 |
| Hazard Information | Back Directory | [Uses]
BLT-4 is a specific, reversible inhibitor of scavenger receptor, class B, type I (SR-BI). BLT-4 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. [1]. | [Definition]
ChEBI: N-(2-methoxyphenyl)-N'-(2-naphthyl)urea is a member of the class of phenylureas that is N-(2-methoxyphenyl)urea in which one of the two protons on the free NH2 function has been replaced by a 2-naphthyl group. It is a member of naphthalenes, a member of phenylureas and a monomethoxybenzene. | [Biochem/physiol Actions]
BLT-4 is a blocker of lipid transport-4 (BLT-4). BLT-4 is a specific, reversible inhibitor of scavenger receptor, class B, type I (SR-BI) mediated lipid transfer. The molecule blocks the cellular uptake and transfer of cholesterol ester from HDL. | [References]
[1] Nieland TJ, et al. Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide. J Lipid Res. 2004;45(7):1256-1265. DOI:10.1194/jlr.M300358-JLR200 |
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| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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