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252003-65-9

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252003-65-9 Structure

252003-65-9 Structure
IdentificationBack Directory
[Name]

CP-547632
[CAS]

252003-65-9
[Synonyms]

CS-1957
CP-547632
CP-547632(CP 547632)
3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carbox
3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxami
3-[(4-Bromo-2,6-difluorobenzyl)oxy]-5-[3-[4-(pyrrolidin-1-yl)butyl]ureido]isothiazole-4-carboxamide
3-(4-Bromo-2,6-difluorobenzyloxy)-5-(3-(4-pyrrolidin-1-ylbutyl)ureido)isothiazole-4-carboxylic acid amide
3-[(4-broMo-2,6-difluorophenyl)Methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]aMino]carbonyl]aMino]-4-isothiazolecarboxaMide
4-Isothiazolecarboxamide, 3-((4-bromo-2,6-difluorophenyl)methoxy)-5-((((4-(1-pyrrolidinyl)butyl)amino)carbonyl)amino)-
[EINECS(EC#)]

200-258-5
[Molecular Formula]

C20H24BrF2N5O3S
[MDL Number]

MFCD07772279
[MOL File]

252003-65-9.mol
[Molecular Weight]

532.4
Chemical PropertiesBack Directory
[Boiling point ]

548.6±50.0 °C(Predicted)
[density ]

1.532
[storage temp. ]

Sealed in dry,2-8°C
[solubility ]

DMSO: 94 mM
[form ]

A solid
[pka]

12.50±0.70(Predicted)
[color ]

White to light yellow
Hazard InformationBack Directory
[Description]

CP 547,632 is an orally bioavailable and potent inhibitor of the receptor tyrosine kinases VEGF receptor 2 (VEGFR2) and basic fibroblast growth factor (bFGF) with IC50 values of 11 and 9 nM, respectively, in an enzyme assay. It is selective for VEGFR2 and bFGF over EGFR, PDGF receptor β (PDGFRβ), and related tyrosine kinases. CP 547,632 inhibits VEGFR2 autophosphorylation induced by VEGF in porcine aortic endothelial cells transfected with VEGFR2 (IC50 = 6 nM) and in a xenograft mouse model using NIH3T3/H-Ras cells (EC50 = 590 nM). It decreases angiogenesis induced by VEGF or bFGF and suppresses tumor growth in athymic mice.
Spectrum DetailBack Directory
[Spectrum Detail]

CP-547632(252003-65-9)1HNMR
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