| Identification | Back Directory | [Name]
2-Propenoic acid, 3-[1-[(2,4-dichlorophenyl)methyl]-1H-indazol-3-yl]- | [CAS]
252025-48-2 | [Synonyms]
AF2785
AF-2785
AF 2785
AF2785,AF 2785
2-Propenoic acid, 3-[1-[(2,4-dichlorophenyl)methyl]-1H-indazol-3-yl]- | [Molecular Formula]
C17H12Cl2N2O2 | [MOL File]
252025-48-2.mol | [Molecular Weight]
347.2 |
| Hazard Information | Back Directory | [Uses]
AF-2785 is a potent CFTR blocker. AF-2785 inhibits the cAMP-activated chloride current in rat epididymal cells with an IC50 of 170.6 μM. AF-2785 can be used in research related to contraceptives[1]. | [References]
[1] Gong XD, et al. Lonidamine and analogue AF2785 block the cyclic adenosine 3', 5'-monophosphate-activated chloride current and chloride secretion in the rat epididymis. Biol Reprod. 2000 Sep;63(3):833-8. DOI:10.1095/biolreprod63.3.833 |
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