| Identification | Back Directory | [Name]
Methanone, [4-(3,5-dimethoxyphenyl)-1-piperazinyl](5-methyl-4-phenyl-4H-1,2,4-triazol-3-yl)- | [CAS]
2521560-46-1 | [Synonyms]
Tubulin polymerization-IN-30
Methanone, [4-(3,5-dimethoxyphenyl)-1-piperazinyl](5-methyl-4-phenyl-4H-1,2,4-triazol-3-yl)- | [Molecular Formula]
C22H25N5O3 | [MOL File]
2521560-46-1.mol | [Molecular Weight]
407.47 |
| Hazard Information | Back Directory | [Uses]
Tubulin polymerization-IN-30 (compound 6e) is a potent Tubulin polymerization inhibitor. Tubulin polymerization-IN-30 is a colchicine binding site inhibitor. Tubulin polymerization-IN-30 can disrupt intracellular microtubule organization, arrest cell cycle at the G2/M phase. Tubulin polymerization-IN-30 exhibits the high potency against the cancer cell lines including SGC-7901, A549 and HeLa, with IC50 values of 2.16, 2.21, and 0.403 μM[1]. | [References]
[1] Wang C, et al. Design, synthesis and evaluation of antiproliferative and antitubulin activities of 5-methyl-4-aryl-3-(4-arylpiperazine-1-carbonyl)-4H-1,2,4-triazoles. Bioorg Chem. 2020 Nov;104:103909. DOI:10.1016/j.bioorg.2020.103909 |
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