| Identification | Back Directory | [Name]
(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol | [CAS]
252555-01-4 | [Synonyms]
ACOLBIFENE (hydrochloride)
BYQDPIXWTVEVEA-JMAPEOGHSA-N
(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol
(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2H-chromen-7-ol,hydrochloride | [Molecular Formula]
C29H31NO4 | [MDL Number]
MFCD32645228 | [MOL File]
252555-01-4.mol |
| Hazard Information | Back Directory | [Uses]
Prevention
or treatment of breast and uterine proliferation or cancer. | [in vivo]
Acolbifene (ACOL) reduces food intake and strongly decreases cholesterolemia in rats fed a cholesterol-free diet[2].
Acolbifene (ACOL) reduces food intake (16%) and weight gain (45%, mainly fat) similarly in both dietary cohorts[2].
| Animal Model: | Female Sprague-Dawley rats (n = 42) initially weighing 175-200 g[2]. | | Dosage: | 2.5 mg/kg. | | Administration: | Oral gavage, once daily for 21 d. | | Result: | Prevents tumor growth in rats. |
| [IC 50]
ERα: 2 nM (IC50, E2-induced transcriptional activity); ERβ: 0.4 nM (IC50, E2-induced transcriptional activity) |
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