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252557-97-4

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252557-97-4 Structure

252557-97-4 Structure
IdentificationBack Directory
[Name]

Z-Ile-Glu-Pro-Phe-OMe
[CAS]

252557-97-4
[Synonyms]

CH 5450
Z-Ile-Glu-Pro-Phe-OMe
Z-ILE-GLU-PRO-PHE-CO2ME
Z-Ile-Glu-Pro-Phe-Ome, BR
CH-5450 (Z-Ile-Glu-Pro-Phe-CO2Me)
L-Phenylalanine, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-α-glutamyl-L-prolyl-, 4-methyl ester
[Molecular Formula]

C34H44N4O9
[MDL Number]

MFCD28167838
[MOL File]

252557-97-4.mol
[Molecular Weight]

652.75
Chemical PropertiesBack Directory
[Boiling point ]

928.4±65.0 °C(Predicted)
[density ]

1.251±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

4.48±0.10(Predicted)
[color ]

White to off-white
[Sequence]

Z-Ile-Glu-Pro-Phe-OMe
Hazard InformationBack Directory
[Uses]

CH 5450 (Z-Ile-Glu-Pro-Phe-Ome) is a selective short peptide human cardiac chymase inhibitor. CH-5450 inhibits the action of rat MAB elastase 2 on substrate Ang I with an IC50 value of 49 μM and N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide with an IC50 value of 4.8 μM[1].
[References]

[1] Carlos F Santos, et al. Kinetic characterization and inhibition of the rat MAB elastase-2, an angiotensin I-converting serine protease. Can J Physiol Pharmacol. 2002 Jan;80(1):42-7. DOI:10.1139/y02-004
Spectrum DetailBack Directory
[Spectrum Detail]

Z-Ile-Glu-Pro-Phe-OMe(252557-97-4)1HNMR
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