| Identification | Back Directory | [Name]
2-phenyl-1,2-benzisothiazol-3-(2H)-one | [CAS]
2527-03-9 | [Synonyms]
PZ-25
RP-62373
PD086291
2-phenyl-1,2-benzothiazol-3-one
2-Phenyl-1-thia-2-azaindan-3-one
2-phenylbenzo[d]isothiazol-3(2H)-one
2-phenyl-1,2-benzisothiazol-3-(2H)-one
1,2-Benzisothiazol-3(2H)-one, 2-phenyl-
2-Phenyl-2,3-dihydro-1,2-benzoisothiazole-3-one | [Molecular Formula]
C13H9NOS | [MOL File]
2527-03-9.mol | [Molecular Weight]
227.28 |
| Chemical Properties | Back Directory | [Melting point ]
139-140 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
388.9±25.0 °C(Predicted) | [density ]
1.338±0.06 g/cm3(Predicted) | [pka]
-0.55±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase (TryR) of Trypanosoma brucei, with IC50 values of 61-293 nM for Trypanosoma brucei. Ebsulfur can be used for the research of African trypanosomiasis[1]. | [References]
[1] Lu J, et al. Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase of Trypanosoma brucei. J Biol Chem. 2013 Sep 20;288(38):27456-27468. DOI:10.1074/jbc.M113.495101 |
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