Identification | Back Directory | [Name]
ispronicline | [CAS]
252870-53-4 | [Synonyms]
TC-1734 TC-01734 AZD-3480 ispronicline TC-1734; AZD-3480 Ispronicline (TC-1734 AZD-3480) galactaric acid salt Ispronicline(TC-1734, AZD-3480) (2S,4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine (2S,4E)-5-(5-isopropoxypyridin-3-yl)-N-Methylpent-4-en-2-aMine (E,2S)-N-methyl-5-(5-propan-2-yloxypyridin-3-yl)pent-4-en-2-amine 4-Penten-2-amine, N-methyl-5-[5-(1-methylethoxy)-3-pyridinyl]-, (2S,4E)- Ispronicline, (2S,4E)-5-(5-isopropoxypyridin-3-yl)-N-Methylpent-4-en-2-aMine | [Molecular Formula]
C14H22N2O | [MOL File]
252870-53-4.mol | [Molecular Weight]
234.34 |
Chemical Properties | Back Directory | [Boiling point ]
bp0.5 90-100° | [density ]
0.977±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (426.73 mM; Need ultrasonic) | [form ]
Liquid | [pka]
10.03±0.10(Predicted) | [color ]
Colorless to light yellow |
Hazard Information | Back Directory | [Uses]
Treatment of cognitive and memory disorders
(neuronal nicotinic receptor partial agonist). | [in vivo]
Ispronicline (10-20 mg/kg; s.c.) induces c-Fos expression in selective regions of the rat forebrain[1].
Ispronicline pharmacokinetics (half-life of 2 h in rats) contrasts with the long-lasting improvement of working memory (18 h to 2 d)[2]. Animal Model: | Male Wistar rats weighting 180-200 g[1] | Dosage: | 10 and 30 mg/kg | Administration: | s.c. | Result: | Induced c-Fos in medial paraventricular nucleus of hypothalamus. Treatment with 30 mg/kg ispronicline, but not 10 mg/kg, increased the number of c-Fos immunoreactive cells significantly as compared to controls within the medial parvocellular part of paraventricular nucleus (PVN).
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