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252870-53-4

252870-53-4 Structure

252870-53-4 Structure
IdentificationBack Directory
[Name]

ispronicline
[CAS]

252870-53-4
[Synonyms]

TC-1734
TC-01734
AZD-3480
ispronicline
TC-1734; AZD-3480
Ispronicline (TC-1734
AZD-3480) galactaric acid salt
Ispronicline(TC-1734, AZD-3480)
(2S,4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine
(2S,4E)-5-(5-isopropoxypyridin-3-yl)-N-Methylpent-4-en-2-aMine
(E,2S)-N-methyl-5-(5-propan-2-yloxypyridin-3-yl)pent-4-en-2-amine
4-Penten-2-amine, N-methyl-5-[5-(1-methylethoxy)-3-pyridinyl]-, (2S,4E)-
Ispronicline, (2S,4E)-5-(5-isopropoxypyridin-3-yl)-N-Methylpent-4-en-2-aMine
[Molecular Formula]

C14H22N2O
[MOL File]

252870-53-4.mol
[Molecular Weight]

234.34
Chemical PropertiesBack Directory
[Boiling point ]

bp0.5 90-100°
[density ]

0.977±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 100 mg/mL (426.73 mM; Need ultrasonic)
[form ]

Liquid
[pka]

10.03±0.10(Predicted)
[color ]

Colorless to light yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
Hazard InformationBack Directory
[Uses]

Treatment of cognitive and memory disorders (neuronal nicotinic receptor partial agonist).
[in vivo]

Ispronicline (10-20 mg/kg; s.c.) induces c-Fos expression in selective regions of the rat forebrain[1]. Ispronicline pharmacokinetics (half-life of 2 h in rats) contrasts with the long-lasting improvement of working memory (18 h to 2 d)[2].

Animal Model:Male Wistar rats weighting 180-200 g[1]
Dosage:10 and 30 mg/kg
Administration:s.c.
Result:Induced c-Fos in medial paraventricular nucleus of hypothalamus. Treatment with 30 mg/kg ispronicline, but not 10 mg/kg, increased the number of c-Fos immunoreactive cells significantly as compared to controls within the medial parvocellular part of paraventricular nucleus (PVN).
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