| Identification | Back Directory | [Name]
CHIR-98023 | [CAS]
252916-76-0 | [Synonyms]
CHIR-837
CT-98023
CHIR-98023
UNII-CMQ1L0E91Y
1,2-Ethanediamine, N1-[4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)-2-pyrimidinyl]-N2-(5-nitro-2-pyridinyl)- | [Molecular Formula]
C20H16Cl2N8O2 | [MOL File]
252916-76-0.mol | [Molecular Weight]
471.3 |
| Hazard Information | Back Directory | [Uses]
CHIR-98023 is a potent, selective and reversible inhibitor of GSK3, with IC50s of 10 nM and 6.7 nM for GSK3α and GSK3β, respectively. CHIR-98023 can improve insulin action and glucose metabolism[1][2]. | [IC 50]
GSK3α: 10 nM (IC50); GSK3β: 6.7 nM (IC50) | [References]
[1] Cline GW, et, al. Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats. Diabetes. 2002 Oct;51(10):2903-10. DOI:10.2337/diabetes.51.10.2903
[2] Hu M, et, al. Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells. J Neurochem. 2008 Aug;106(3):1371-7. DOI:10.1111/j.1471-4159.2008.05483.x |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|