| Identification | Back Directory | [Name]
1H-1,2,4-Triazole-3-carboxylic acid, 5-(chloromethyl)-1-(4-fluorophenyl)-, methyl ester | [CAS]
2529451-43-0 | [Synonyms]
COX-2-IN-20
1H-1,2,4-Triazole-3-carboxylic acid, 5-(chloromethyl)-1-(4-fluorophenyl)-, methyl ester | [Molecular Formula]
C11H9ClFN3O2 | [MOL File]
2529451-43-0.mol | [Molecular Weight]
269.66 |
| Hazard Information | Back Directory | [Uses]
COX-2-IN-20 (Compound 5d) is a selective and orally active COX-2 inhibitor with an IC50 of 17.9 nM. COX-2-IN-20 shows anti-inflammatory activity[1]. | [in vivo]
COX-2-IN-20 (Compound 5d) (5 mg/kg) exhibits better in vivo anti-inflammation and gastric protection than 10 mg/kg Indomethacin[1]. | [IC 50]
COX-2: 17.9 nM (IC50); COX-1: 19.3 μM (IC50) | [References]
[1] Li SM, et al. New methyl 5-(halomethyl)-1-aryl-1H-1,2,4-triazole-3-carboxylates as selective COX-2 inhibitors and anti-inflammatory agents: Design, synthesis, biological evaluation, and docking study. Bioorg Chem. 2020 Nov;104:104333. DOI:10.1016/j.bioorg.2020.104333 |
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