25297-52-3

67-56-1

39621-00-6

25297-52-3

The general procedure for synthesizing 2-chloro-6-methoxy-4-methylpyridine from methanol and 2,6-dichloro-4-methylpyridine is as follows: referring to the method of Example 53; 2,6-dichloro-4-methylpyridine (250 mg, 1.5 mmol) was dissolved in methanol (2 mL), and this solution was then added to a pre-prepared sodium methanol solution (prepared by the reaction of sodium (71 mg, 3.0 mmol ) was prepared by reacting with anhydrous methanol in a total volume of about 20 mL). Subsequently, the reaction mixture was heated to reflux for 48 hours. Upon completion of the reaction, the solvent was removed by evaporation and the residue was extracted by partitioning with water and dichloromethane. The organic layer was separated, washed sequentially with water and brine, and then dried over anhydrous sodium sulfate. Finally, the dried organic phase was concentrated to afford the target product 2-chloro-6-methoxy-4-methylpyridine (150 mg, 61% yield) as a light orange oily liquid.