| Identification | Back Directory | [Name]
Eribulin intermediate | [CAS]
253128-15-3 | [Synonyms]
ER-076349
Eribulin N-3
Eribulin Impurity 12
(1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,35R...
Eribulin Impurity 12Q: What is
Eribulin Impurity 12 Q: What is the CAS Number of
Eribulin Impurity 12
11,15:18,21:24,28-Triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2-i]furo[2',3':5,6]pyrano[4,3-b][1,4]dioxacyclopentacosin-5(4H)-one, 2-[(2S)-2,3-dihydroxypropyl]hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)-, (2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)- | [Molecular Formula]
C40H58O12 | [MDL Number]
MFCD30532881 | [MOL File]
253128-15-3.mol | [Molecular Weight]
730.88 |
| Hazard Information | Back Directory | [Uses]
ER-076349 (Eribulin intermediate) is an inhibitor of tubulin polymerization, induces G2-M cell cycle arrest, and disrupts mitotic spindles. ER-076349 inhibits cancer cell growth, and inhibits tumor growth in several human tumor xenografts. ER-076349 is an analog of Halichondrin B[1]. | [References]
[1] Towle MJ, et al. In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B. Cancer Res. 2001 Feb 1;61(3):1013-21. PMID:11221827 |
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