| Identification | Back Directory | [Name]
9H-Pyrido[3,4-b]indole-3-carboxamide, N-[5-(1H-indol-2-yl)-1,3,4-thiadiazol-2-yl]-1-(4-methoxyphenyl)- | [CAS]
2538528-11-7 | [Synonyms]
Topoisomerase IIα-IN-3
9H-Pyrido[3,4-b]indole-3-carboxamide, N-[5-(1H-indol-2-yl)-1,3,4-thiadiazol-2-yl]-1-(4-methoxyphenyl)- | [Molecular Formula]
C29H20N6O2S | [MOL File]
2538528-11-7.mol | [Molecular Weight]
516.57 |
| Hazard Information | Back Directory | [Uses]
Topoisomerase IIα-IN-3 (Compound 12c) is a DNA intercalative topoisomerase-IIα inhibitor. Topoisomerase IIα-IN-3 arrests cell cycle at the G0/G1 phase and induces apoptosis[1]. | [IC 50]
topoisomerase II alpha | [References]
[1] Tokala R, et al. Design and synthesis of thiadiazolo-carboxamide bridged β-carboline-indole hybrids: DNA intercalative topo-IIα inhibition with promising antiproliferative activity. Bioorg Chem. 2020 Dec;105:104357. DOI:10.1016/j.bioorg.2020.104357 |
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