| Identification | Back Directory | [Name]
N-ISOBUTYL-2,6,8-DECATRIENAMIDE | [CAS]
25394-57-4 | [Synonyms]
AFFININ
SPILANTHOL
SPILANTHOL(P)
spilanthol(25394-57-4)
N-ISOBUTYL-2,6,8-DECATRIENAMIDE
(2E,6Z,8E)-N-Isobutyl-2,6,8-decatrienamide
2,6,8-DecatrienaMide,N-(2-Methylpropyl)-, (2E,6Z,8E)-
2,6,8-Decatrienamide,N-(2-methylpropyl)-, (2E,6Z,8E)- CAS NO.25394-57-4 | [Molecular Formula]
C14H23NO | [MOL File]
25394-57-4.mol | [Molecular Weight]
221.34 |
| Chemical Properties | Back Directory | [Melting point ]
23° | [Boiling point ]
bp0.2 141°; bp0.3-0.5 160-165° | [density ]
0.896±0.06 g/cm3(Predicted) | [FEMA ]
4668 | (2E,6E/Z,8E)-N-(2-METHYLPROPYL)-2,6,8-DECATRIENAMIDE | [refractive index ]
nD25 1.5134 | [storage temp. ]
Amber Vial, -86°C Freezer, Under inert atmosphere | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
15.07±0.46(Predicted) | [color ]
Colourless to Yellow Oil | [Odor]
at 100.00 %. fruity | [Odor Type]
fruity | [JECFA Number]
2077 | [Stability:]
Light Sensitive, Temperature Sensitive | [LogP]
3.18 |
| Hazard Information | Back Directory | [Uses]
Insecticide synergist. | [Uses]
Spilanthol is a fatty acid amide isolated from Acmella oleracea. Spilanthol extract has been discovered to aid in saliva stimulation (sialogogue) for people suffering from dry mouth (xerostomia). | [Synthesis Reference(s)]
Tetrahedron Letters, 25, p. 5177, 1984 DOI: 10.1016/S0040-4039(01)81556-2 | [in vivo]
Spilanthol ( 1-1.875 mg/kg, Ip, Once) shows antinociceptive activity in acetic acid-induced abdominal writhes Male ICR mice model and capsaicin-induced licking paw Male ICR mice model[2].
Spilanthol (30 mg/kg, Po, Once a day for four days) a protective effect against the intestinal damage associated in swiss mice model of intestinal mucositis induced by 5-fluorouracil (HY-90006)[4].
Spilanthol (800 mg/kg, Po, Once) has a diuretic effect in adult C57BL/6J male mice[5]. | Animal Model: | Acetic acid-induced abdominal writhes Male ICR mice model[2] | | Dosage: | 1-1.875 mg/kg | | Administration: | Intraperitoneal administration(i.p.), Once | | Result: | As the dose increased, the number of abdominal contractions and licking behavior decreased, and a maximum antinociceptive effect of 46.67% |
| Animal Model: | Swiss mice model of intestinal mucositis induced by 5-fluorouracil[4]. | | Dosage: | 30 mg/kg | | Administration: | Oral adminstraion(p.o.), Once a day for four days | | Result: | Showed the intestinal wall recovery, villi are higher and less irregularity and high number and greater length of intestinal crypts. |
| Animal Model: | Adult C57BL/6J male mice[5]. | | Dosage: | 800 mg/Kg | | Administration: | Oral adminstraion (p.o.), Once | | Result: | Increased in urine output, sodium, and increased excretion of sodium, potassium and chloride. |
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