| Identification | Back Directory | [Name]
1,6-Naphthyridin-2(1H)-one, 3-(3-hydroxyphenyl)-1-methyl-7-[[3-(4-methyl-1-piperazinyl)phenyl]amino] | [CAS]
2540881-21-6 | [Synonyms]
UH15-38
3-(3-Hydroxyphenyl)-1-methyl-7-((3-(4-methylpiperazin-1-yl)phenyl)amino)-1,6-naphthyridin-2(1H)-one
1,6-Naphthyridin-2(1H)-one, 3-(3-hydroxyphenyl)-1-methyl-7-[[3-(4-methyl-1-piperazinyl)phenyl]amino] | [Molecular Formula]
C26H27N5O2 | [MOL File]
2540881-21-6.mol | [Molecular Weight]
441.53 |
| Chemical Properties | Back Directory | [Boiling point ]
650.3±55.0 °C(predicted) | [density ]
1.297±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
9.50±0.10(predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
UH15-38 is a potent RIPK3 inhibitor with an IC50 value of 20 nM. UH15-38 blocks IAV (influenza A virus)-activated necroptosis. UH15-38 dampens IAV-induced lung injury[1]. | [in vivo]
UH15-38 (30 mg/kg; i.p.; daily for 4 days) dampens IAV (influenza A virus)-induced lung injury[1]. | Animal Model: | C57Bl/6 mice (lethal dose of PR8 (6,000?×?EID50))[1] | | Dosage: | 30 mg/kg | | Administration: | I.p.; once daily for 4 days; starting 24?h after infection | | Result: | Markedly reduced numbers of pMLKL+ necroptotic cells, decreased in diffuse alveolar damage and the formation of hyaline membranes, reduced the extent of fibrotic lung damage, displayed significantly lower levels of the pro-fibrotic mediators (IL-1β, IL-6, IL-18, IL-17 and CCL5). |
| [IC 50]
RIPK3: 20 nM (IC50) | [References]
[1] Gautam A, et al. Necroptosis blockade prevents lung injury in severe influenza. Nature. 2024 Apr;628(8009):835-843. DOI:10.1038/s41586-024-07265-8 |
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| Company Name: |
R&D Systems, Inc
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18003437475 18003437475 |
| Website: |
www.rndsystems.com |
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