| Identification | Back Directory | [Name]
DCN1-IN-2 | [CAS]
2543578-57-8 | [Synonyms]
DCN1-IN-2
4H-1,2,4-Triazole-4-propanamide, 3-(4-chlorophenyl)-1,5-dihydro-5-thioxo-N-[3-(trifluoromethyl)phenyl]- | [Molecular Formula]
C18H14ClF3N4OS | [MOL File]
2543578-57-8.mol | [Molecular Weight]
426.84 |
| Hazard Information | Back Directory | [Uses]
DCN1-IN-2 is a DCN1 inhibitor with an IC50 value of 2.96 nM. DCN1-IN-2 can alleviate Ang II/TGFβ-induced activation of cardiac fibroblasts. DCN1-IN-2 can reduce ISO-induced cardiac fibrosis and remodeling in mice by selectively inhibiting cullin 3[1]. | [References]
[1] He ZX, et al. Discovery of 1,2,4-Triazole-3-thione Derivatives as Potent and Selective DCN1 Inhibitors for Pathological Cardiac Fibrosis and Remodeling. J Med Chem. 2024 Aug 19. DOI:10.1021/acs.jmedchem.4c00713 |
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