| Identification | Back Directory | [Name]
EGFR-IN-123 | [CAS]
2543763-00-2 | [Synonyms]
EGFR-IN-123
4,6-Pyrimidinediamine, N4-(3-methoxyphenyl)-N6-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]- | [Molecular Formula]
C24H27F3N6O | [MOL File]
2543763-00-2.mol | [Molecular Weight]
472.51 |
| Chemical Properties | Back Directory | [Boiling point ]
565.2±50.0 °C(predicted) | [density ]
1.301±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
7.55±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
EGFR-IN-123 (compound D06) is a potent EGFR inhibitor. EGFR-IN-123 inhibits PC-9G, A549, A431 and HCT116 cells with IC50s of 0.74, 1.36, 1.20 and 2.53 μM, respectively[1]. | [References]
[1] FaQing Ye,et al. N4- (3-methoxyphenyl) -pyrimidinediamine targeted DDR1 inhibitor and preparation and application thereof. CN, CN111793035B. 2021-06-18.
[2] FaQing Ye,et al. N4- (3-methoxyphenyl) -pyrimidinediamine targeted DDR1 inhibitor and preparation and application thereof. CN, CN111793035B. 2021-06-18. |
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