| Identification | Back Directory | [Name]
alisporivir | [CAS]
254435-95-5 | [Synonyms]
DEB-025
Debio-025
alisporivir
Trofinetide
Alisporivir (Debio-025)
alisporivir /DB025/DB-025 | [Molecular Formula]
C63H113N11O12 | [MDL Number]
MFCD32694261 | [MOL File]
254435-95-5.mol | [Molecular Weight]
1216.66 |
| Chemical Properties | Back Directory | [Boiling point ]
1294.2±65.0 °C(Predicted) | [density ]
1.011±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 100 mg/mL (82.19 mM) | [form ]
Solid | [pka]
13.32±0.70(Predicted) | [color ]
White to off-white | [Sequence]
Cyclo({N-Me-Bmt(E)}-{Abu}-{d-N-Me-Ala}-{N-Et-Val)-Val-{N-Me-Leu}-Ala-{d-Ala}-{N-Me-Leu}-{N-Me-Leu}-{N-Me-Val}) |
| Hazard Information | Back Directory | [Uses]
Trofinetide is a synthetic analogue of the endogenous N-terminus tripeptide, Glycine-Proline-Glutamate (GPE), that has shown to be neuroprotective in animal models of brain injury. | [Definition]
ChEBI: Alisporivir is a homodetic cyclic peptide. It has a role as an anticoronaviral agent. | [Biological Activity]
Alisporivir is a Cyclophilin A inhibitor with potent anti-hepatitis C virus (HCV) activity. Alisporivir has also been investigated for Duchenne muscular dystrophy. | [in vivo]
Combination treatment with Alisporivir and ICN-1229 does not protect against SARS-CoV infection in a mouse model[3]. | [storage]
Store at -20°C |
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