2549199-96-2

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2549199-96-2 Structure

Identification	Back Directory
[Name] Mtb-IN-8
[CAS] 2549199-96-2
[Synonyms] Mtb-IN-8 Pyrido[2,3-d]pyrimidine-4,7(3H,6H)-dione, 5,8-dihydro-5-(4-methoxy-2-nitrophenyl)-2-(propylthio)-
[Molecular Formula] C17H18N4O5S
[MOL File] 2549199-96-2.mol
[Molecular Weight] 390.42

Chemical Properties	Back Directory
[density ] 1.53±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 14.52±0.40(predicted)

Hazard Information	Back Directory
[Uses] Mtb-IN-8 (compound 5jb) is an orally active inhibitor of Mycobacterium tuberculosis (Mtb) with MIC values of 0.03 μg/mL for H37Rv and 0.125-0.06 μg/mL for MDR-Mtb, respectively[1].
[References] [1] Sun L,et al. Design, Synthesis, and Evaluation of the Antitubercular Activity of 5-Phenyl Substituted-5, 6-dihydropyrido[2, 3-d]pyrimidine-4, 7(3H, 8H)-dione Compounds. J Med Chem. 2024 Sep 12;67(17):14927-14945. DOI:10.1021/acs.jmedchem.4c00441

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