| Identification | Back Directory | [Name]
4-[4-[[3-[3-Bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1(2H)-pyridinyl]-4-methylbenzoyl]amino]butyl]-N-[4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]butyl]-1H-1,2,3-triazole-1-butanamide | [CAS]
2550399-06-7 | [Synonyms]
4-[4-[[3-[3-Bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1(2H)-pyridinyl]-4-methylbenzoyl]amino]butyl]-N-[4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]butyl]-1H-1,2,3-triazole-1-butanamide
3-{3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1,2-dihydropyridin-1-yl}-N-[4-(1-{3-[(4-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}butyl)carbamoyl]propyl}-1H-1,2,3-triazol-4-yl)butyl]-4-methylbenzamide | [Molecular Formula]
C48H50BrF2N9O8 | [MOL File]
2550399-06-7.mol | [Molecular Weight]
998.87 |
| Hazard Information | Back Directory | [Uses]
NR-7h is a potent and selective p38α and p38β degrader with DC50 values of 24 nM and 27.2 nM for p38α in T47D, MB-MDA-231 cells, respectively[1]. | [References]
[1] Donoghue C, et al. Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation. Eur J Med Chem. 2020 Sep 1;201:112451. DOI:10.1016/j.ejmech.2020.112451 |
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R&D Systems, Inc
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18003437475 18003437475 |
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www.rndsystems.com |
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